TAPs. The safe and easy way to multi-particulate dosage forms
Multi-particulate dosage forms have striking advantages compared to monolithic dosage forms, such as:
- low variability of gastric emptying
- low dependency on nutrition state
- low risk of localized high drug concentrations in the GI
- reduced risk of sudden dose dumping
- lower intra- and inter-individual variability
- high control on time and place of drug delivery
This means firstly higher safety and secondly better compliance for your patients, and added-value for your products.
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TAP is a great offering for our clients that have a drug that shows pH dependent solubility and requires an acidic environment to improve solubility, release, and absorption. The TAP pellets can do a great job of creating the acidic microenvironment required to make their drug successful.
APIs with poor solubility in alkalic media, like in the intestine, sometimes need a kick with a small acidic environment and we are happy to support our customers with TAP® as excipient for this dilemma.
Our project partners love to work with TAPs, as they accelerate the dissolution rate of weakly basic drugs creating the best in-situ micro-environment conditions. You get TAPs in diverse sizes – perfect for multi-particulate formulations!
The development of solid dosage forms with tartaric acid pellets is one of Glatt Pharmaceutical Services’ specialty, with focus on complex formulations and vast expertise for multiparticulate systems. The development and manufacturing centers with FDA and EU-GMP certification are well equipped for all your requirements. New technologies are in charge for the realization of your product ideas. Also for demanding ingredients.
- Sites and cGMP facilities in Germany & USA
- Strong core competence
- Solution oriented
- Flexible setup
- Full service