Abstract Dabigatran etexilate mesylate is a pro-drug of Dabigatran – a BSC Class II drug used as anti-coagulant in deep vein thrombosis as a direct thrombin inhibitor. Due to increasing solubility in the acidic regime, tartaric acid pellets (TAP) are used as starter beads. A processed formulation is compared with the existing formulation from the […]
APIs of BSC Class IV in oral formulations represent one of four groups following the Biopharmaceutical Classification System (BCS). The BCS predicts potential effects of oral formulations on the human drug oral bioavailability. Thereby, it is a scientific tool differentiating the drug substances on the basis of solubility and intestinal permeability under prescribed condition. While […]
Abstract The objective of this study is to investigate the influence of tartaric acid pellets on the release behavior of a basic drug. By applying an acid micro-environment, the release profiles of Papaverine HCI was dramatically improved. Formulations with weakly basic drugs Papaverine HCl is an opium alkaloid antispasmodic drug, used in the treatment of […]
Introduction We will introduce tartaric acid starter pellets as pH-modifier for basic drugs. Tartaric acid is widely used in food products, oral, topical and parenteral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. In general, tartaric acid is also used in beverages, confectionary, food products and pharmaceutical formulations as an acidulant, […]
linkedin
